Endothelin-1 critically influences cardiac function via superoxide-MMP9 cascade

We have generated low-expressing and high-expressing endothelin-1 genes (L and H) and have bred mice with four levels of expression: L/L, ∼20%; L/+, ∼65%; +/+ (wild type), 100%; and H/+, ∼350%. The hypomorphic L allele can be spatiotemporally switched to the hypermorphic H allele by Cre-loxP recombi...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Hathaway, Catherine K., Grant, Ruriko, Hagaman, John R., Hiller, Sylvia, Li, Feng, Xu, Longquan, Chang, Albert S., Madden, Victoria J., Bagnell, C. Robert, Rojas, Mauricio, Kim, Hyung-Suk, Wu, Bingruo, Zhou, Bin, Smithies, Oliver, Kakoki, Masao
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413291/
https://ncbi.nlm.nih.gov/pubmed/25848038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1504557112
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