Primary aldosteronism and impaired natriuresis in mice underexpressing TGFβ1

To uncover the potential cardiovascular effects of human polymorphisms influencing transforming growth factor β1 (TGFβ1) expression, we generated mice with Tgfb1 mRNA expression graded in five steps from 10% to 300% normal. Adrenal expression of the genes for mineralocorticoid-producing enzymes rang...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Kakoki, Masao, Pochynyuk, Oleh M., Hathaway, Catherine M., Tomita, Hirofumi, Hagaman, John R., Kim, Hyung-Suk, Zaika, Oleg L., Mamenko, Mykola, Kayashima, Yukako, Matsuki, Kota, Hiller, Sylvia, Li, Feng, Xu, Longquan, Grant, Ruriko, Bertorello, Alejandro M., Smithies, Oliver
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2013
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3619322/
https://ncbi.nlm.nih.gov/pubmed/23503843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1302641110
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