Salt-dependent inhibition of ENaC-mediated sodium reabsorption in the aldosterone-sensitive distal nephron by bradykinin

We have recently documented that Bradykinin (BK) directly inhibits activity of the Epithelial Na(+) Channel (ENaC) via B2R-G(q/11)-PLC pathway. In this study, we took advantage of mice genetically engineered to lack bradykinin receptors (B1R,B2R-/-) to probe a physiological role of BK cascade in reg...

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Bibliographic Details
Main Authors:	Mamenko, Mykola, Zaika, Oleg, Doris, Peter A., Pochynyuk, Oleh
Format:	Artigo
Language:	Inglês
Published:	2012
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3475746/ https://ncbi.nlm.nih.gov/pubmed/23033373 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.112.200469
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Salt-dependent inhibition of ENaC-mediated sodium reabsorption in the aldosterone-sensitive distal nephron by bradykinin

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