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Salt-dependent inhibition of ENaC-mediated sodium reabsorption in the aldosterone-sensitive distal nephron by bradykinin

We have recently documented that Bradykinin (BK) directly inhibits activity of the Epithelial Na(+) Channel (ENaC) via B2R-G(q/11)-PLC pathway. In this study, we took advantage of mice genetically engineered to lack bradykinin receptors (B1R,B2R-/-) to probe a physiological role of BK cascade in reg...

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Main Authors: Mamenko, Mykola, Zaika, Oleg, Doris, Peter A., Pochynyuk, Oleh
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3475746/
https://ncbi.nlm.nih.gov/pubmed/23033373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.112.200469
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