Purinergic Activation of Ca(2+)-Permeable TRPV4 Channels Is Essential for Mechano-Sensitivity in the Aldosterone-Sensitive Distal Nephron

Mechanical forces are known to induce increases of [Ca(2+)](i) in the aldosterone-sensitive distal nephron (ASDN) cells to regulate epithelial transport. At the same time, mechanical stress stimulates ATP release from ASDN cells. In this study, we combined ratiometric Fura-2 based monitoring of [Ca(...

Full description

Saved in:

Bibliographic Details
Main Authors:	Mamenko, Mykola, Zaika, Oleg, Jin, Min, O'Neil, Roger G., Pochynyuk, Oleh
Format:	Artigo
Language:	Inglês
Published:	Public Library of Science 2011
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3151261/ https://ncbi.nlm.nih.gov/pubmed/21850238 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022824
Tags:	Add Tag No Tags, Be the first to tag this record!

Purinergic Activation of Ca(2+)-Permeable TRPV4 Channels Is Essential for Mechano-Sensitivity in the Aldosterone-Sensitive Distal Nephron

Similar Items