OSU‐03012 and Viagra Treatment Inhibits the Activity of Multiple Chaperone Proteins and Disrupts the Blood–Brain Barrier: Implications for Anti‐Cancer Therapies

We examined the interaction between OSU‐03012 (also called AR‐12) with phosphodiesterase 5 (PDE5) inhibitors to determine the role of the chaperone glucose‐regulated protein (GRP78)/BiP/HSPA5 in the cellular response. Sildenafil (Viagra) interacted in a greater than additive fashion with OSU‐03012 t...

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Bibliografiske detaljer
Udgivet i:J Cell Physiol
Main Authors: Booth, Laurence, Roberts, Jane L., Tavallai, Mehrad, Nourbakhsh, Aida, Chuckalovcak, John, Carter, Jori, Poklepovic, Andrew, Dent, Paul
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2015
Fag:
Original Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4835175/
https://ncbi.nlm.nih.gov/pubmed/25736380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.24977
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