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Bacterial Riboswitches and Ribozymes Potently Activate the Human Innate Immune Sensor PKR

The innate immune system provides the first line of defense against pathogens through the recognition of non-specific patterns in RNA to protect the cell in a generalized way. The human RNA-activated protein kinase, PKR, is a dsRNA binding protein and an essential sensor in the innate immune respons...

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Bibliografiske detaljer
Udgivet i:ACS Chem Biol
Main Authors: Hull, Chelsea M., Anmangandla, Ananya, Bevilacqua, Philip C.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833549/
https://ncbi.nlm.nih.gov/pubmed/27011290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00081
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