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Mechanistic Analysis of Activation of the Innate Immune Sensor PKR by Bacterial RNA
The protein kinase PKR is a sensor in innate immunity. PKR autophosphorylates in the presence of dsRNA enabling it to phosphorylate its substrate, eIF2α, halting cellular translation. Classical activators of PKR are long viral dsRNAs, but recently PKR has been found to be activated by bacterial RNA....
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| Published in: | J Mol Biol |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4624505/ https://ncbi.nlm.nih.gov/pubmed/26026708 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2015.05.018 |
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