Cardiomyocyte-specific conditional knockout of the histone chaperone HIRA in mice results in hypertrophy, sarcolemmal damage and focal replacement fibrosis

HIRA is the histone chaperone responsible for replication-independent incorporation of histone variant H3.3 within gene bodies and regulatory regions of actively transcribed genes, and within the bivalent promoter regions of developmentally regulated genes. The HIRA gene lies within the 22q11.2 dele...

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Detalhes bibliográficos
Publicado no:Dis Model Mech
Main Authors: Valenzuela, Nicolas, Fan, Qiying, Fa'ak, Faisal, Soibam, Benjamin, Nagandla, Harika, Liu, Yu, Schwartz, Robert J., McConnell, Bradley K., Stewart, M. David
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833330/
https://ncbi.nlm.nih.gov/pubmed/26935106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.022889
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