Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice

Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase that plays a major role in integrin signaling pathways. Although cardiovascular defects were observed in FAK total KO mice, the embryonic lethality prevented investigation of FAK function in the hearts of adult animals. To circumvent these...

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Detalhes bibliográficos
Main Authors: Peng, Xu, Kraus, Marc S., Wei, Huijun, Shen, Tang-Long, Pariaut, Romain, Alcaraz, Ana, Ji, Guangju, Cheng, Lihong, Yang, Qinglin, Kotlikoff, Michael I., Chen, Ju, Chien, Kenneth, Gu, Hua, Guan, Jun-Lin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2006
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1319217/
https://ncbi.nlm.nih.gov/pubmed/16374517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI24497
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