Cardiomyocyte-specific conditional knockout of the histone chaperone HIRA in mice results in hypertrophy, sarcolemmal damage and focal replacement fibrosis

HIRA is the histone chaperone responsible for replication-independent incorporation of histone variant H3.3 within gene bodies and regulatory regions of actively transcribed genes, and within the bivalent promoter regions of developmentally regulated genes. The HIRA gene lies within the 22q11.2 dele...

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Dettagli Bibliografici
Pubblicato in:Dis Model Mech
Autori principali: Valenzuela, Nicolas, Fan, Qiying, Fa'ak, Faisal, Soibam, Benjamin, Nagandla, Harika, Liu, Yu, Schwartz, Robert J., McConnell, Bradley K., Stewart, M. David
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Company of Biologists Ltd 2016
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833330/
https://ncbi.nlm.nih.gov/pubmed/26935106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.022889
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