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Cardiomyocyte-specific conditional knockout of the histone chaperone HIRA in mice results in hypertrophy, sarcolemmal damage and focal replacement fibrosis

HIRA is the histone chaperone responsible for replication-independent incorporation of histone variant H3.3 within gene bodies and regulatory regions of actively transcribed genes, and within the bivalent promoter regions of developmentally regulated genes. The HIRA gene lies within the 22q11.2 dele...

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Bibliografski detalji
Izdano u:Dis Model Mech
Glavni autori: Valenzuela, Nicolas, Fan, Qiying, Fa'ak, Faisal, Soibam, Benjamin, Nagandla, Harika, Liu, Yu, Schwartz, Robert J., McConnell, Bradley K., Stewart, M. David
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists Ltd 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833330/
https://ncbi.nlm.nih.gov/pubmed/26935106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.022889
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