ERRγ is required for the metabolic maturation of therapeutically functional glucose-responsive β cells

Pancreatic β cells undergo postnatal maturation to achieve maximal glucose-responsive insulin secretion, an energy intensive process. We identify estrogen-related receptor γ (ERRγ) expression as a hallmark of adult, but not neonatal β cells. Postnatal induction of ERRγ drives a transcriptional netwo...

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Bibliografske podrobnosti
izdano v:Cell Metab
Main Authors: Yoshihara, Eiji, Wei, Zong, Lin, Chun Shi, Fang, Sungsoon, Ahmadian, Maryam, Kida, Yasuyuki, Tseng, Tiffany, Dai, Yang, Yu, Ruth T., Liddle, Christopher, Atkins, Annette R., Downes, Michael, Evans, Ronald M.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832237/
https://ncbi.nlm.nih.gov/pubmed/27076077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2016.03.005
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