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Discovery of a specific inhibitor of human GLUT5 by virtual screening and in vitro transport evaluation
GLUT5, a fructose-transporting member of the facilitative glucose transporter (GLUT, SLC2) family, is a therapeutic target for diabetes and cancer but has no potent inhibitors. We virtually screened a library of 6 million chemicals onto a GLUT5 model and identified N-[4-(methylsulfonyl)-2-nitropheny...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4831007/ https://ncbi.nlm.nih.gov/pubmed/27074918 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24240 |
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