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Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABA(A) receptor subtype

Agonists at the benzodiazepine-binding site of GABA(A) receptors (BDZs) enhance synaptic inhibition through four subtypes (α1, α2, α3 and α5) of GABA(A) receptors (GABA(A)R). When applied to the spinal cord, they alleviate pathological pain; however, insufficient efficacy after systemic administrati...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Ralvenius, William T., Benke, Dietmar, Acuña, Mario A., Rudolph, Uwe, Zeilhofer, Hanns Ulrich
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4829939/
https://ncbi.nlm.nih.gov/pubmed/25865415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7803
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