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The clobazam metabolite N-desmethyl clobazam is an α2 preferring benzodiazepine with an improved therapeutic window for antihyperalgesia
Data from genetically modified mice suggest that benzodiazepine (BDZ)-site agonists with improved selectivity for α2-subtype GABA(A) receptors (α2GABA(A)R) are potentially useful for the treatment of neuropathic pain. Subtype-selective compounds available for preclinical tests in rodents support thi...
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| 出版年: | Neuropharmacology |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Pergamon Press
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4981430/ https://ncbi.nlm.nih.gov/pubmed/27392635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2016.07.004 |
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