Antihyperalgesia by α2-GABA(A) Receptors Occurs Via a Genuine Spinal Action and Does Not Involve Supraspinal Sites

Drugs that enhance GABAergic inhibition alleviate inflammatory and neuropathic pain after spinal application. This antihyperalgesia occurs mainly through GABA(A) receptors (GABA(A)Rs) containing α2 subunits (α2-GABA(A)Rs). Previous work indicates that potentiation of these receptors in the spinal co...

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Hlavní autoři: Paul, Jolly, Yévenes, Gonzalo E, Benke, Dietmar, Lio, Alessandra Di, Ralvenius, William T, Witschi, Robert, Scheurer, Louis, Cook, James M, Rudolph, Uwe, Fritschy, Jean-Marc, Zeilhofer, Hanns Ulrich
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2014
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3870792/
https://ncbi.nlm.nih.gov/pubmed/24045508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2013.221
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