Antihyperalgesia by α2-GABA(A) Receptors Occurs Via a Genuine Spinal Action and Does Not Involve Supraspinal Sites

Drugs that enhance GABAergic inhibition alleviate inflammatory and neuropathic pain after spinal application. This antihyperalgesia occurs mainly through GABA(A) receptors (GABA(A)Rs) containing α2 subunits (α2-GABA(A)Rs). Previous work indicates that potentiation of these receptors in the spinal co...

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Detalhes bibliográficos
Main Authors: Paul, Jolly, Yévenes, Gonzalo E, Benke, Dietmar, Lio, Alessandra Di, Ralvenius, William T, Witschi, Robert, Scheurer, Louis, Cook, James M, Rudolph, Uwe, Fritschy, Jean-Marc, Zeilhofer, Hanns Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3870792/
https://ncbi.nlm.nih.gov/pubmed/24045508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2013.221
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