HZ166, a Novel GABA(A) Receptor Subtype-Selective Benzodiazepine Site Ligand, Is Antihyperalgesic in Mouse Models of Inflammatory and Neuropathic Pain

Diminished GABAergic and glycinergic inhibition in the spinal dorsal horn contributes significantly to chronic pain of different origins. Accordingly, pharmacological facilitation of GABAergic inhibition by spinal benzodiazepines (BDZs) has been shown to reverse pathological pain in animals as well...

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Autors principals: Di Lio, Alessandra, Benke, Dietmar, Besson, Marie, Desmeules, Jules, Daali, Youssef, Wang, Zhi-jian, Edwankar, Rahul, Cook, James M., Zeilhofer, Hanns Ulrich
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566476/
https://ncbi.nlm.nih.gov/pubmed/21145329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2010.11.026
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