HZ166, a Novel GABA(A) Receptor Subtype-Selective Benzodiazepine Site Ligand, Is Antihyperalgesic in Mouse Models of Inflammatory and Neuropathic Pain

Diminished GABAergic and glycinergic inhibition in the spinal dorsal horn contributes significantly to chronic pain of different origins. Accordingly, pharmacological facilitation of GABAergic inhibition by spinal benzodiazepines (BDZs) has been shown to reverse pathological pain in animals as well...

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書誌詳細
主要な著者: Di Lio, Alessandra, Benke, Dietmar, Besson, Marie, Desmeules, Jules, Daali, Youssef, Wang, Zhi-jian, Edwankar, Rahul, Cook, James M., Zeilhofer, Hanns Ulrich
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566476/
https://ncbi.nlm.nih.gov/pubmed/21145329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2010.11.026
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