HZ166, a Novel GABA(A) Receptor Subtype-Selective Benzodiazepine Site Ligand, Is Antihyperalgesic in Mouse Models of Inflammatory and Neuropathic Pain

Diminished GABAergic and glycinergic inhibition in the spinal dorsal horn contributes significantly to chronic pain of different origins. Accordingly, pharmacological facilitation of GABAergic inhibition by spinal benzodiazepines (BDZs) has been shown to reverse pathological pain in animals as well...

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Hlavní autoři: Di Lio, Alessandra, Benke, Dietmar, Besson, Marie, Desmeules, Jules, Daali, Youssef, Wang, Zhi-jian, Edwankar, Rahul, Cook, James M., Zeilhofer, Hanns Ulrich
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566476/
https://ncbi.nlm.nih.gov/pubmed/21145329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2010.11.026
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