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Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABA(A) receptor subtype
Agonists at the benzodiazepine-binding site of GABA(A) receptors (BDZs) enhance synaptic inhibition through four subtypes (α1, α2, α3 and α5) of GABA(A) receptors (GABA(A)R). When applied to the spinal cord, they alleviate pathological pain; however, insufficient efficacy after systemic administrati...
Tallennettuna:
| Julkaisussa: | Nat Commun |
|---|---|
| Päätekijät: | , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Nature Publishing Group
2015
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4829939/ https://ncbi.nlm.nih.gov/pubmed/25865415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7803 |
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