Iron oxide-based nanovector for tumor targeted siRNA delivery in an orthotopic hepatocellular carcinoma xenograft mouse model

Hepatocellular carcinoma (HCC) is one of the deadliest cancers worldwide. Small interfering RNA (siRNA) holds promise as a new class of therapeutics for HCC as it can achieve sequence-specific gene knockdown with low cytotoxicity. However, the main challenge in the clinical application of siRNA lies...

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Pubblicato in:Small
Autori principali: Wang, Kui, Kievit, Forrest M., Sham, Jonathan G., Jeon, Mike, Stephen, Zachary R., Bakthavatsalam, Arvind, Park, James O., Zhang, Miqin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4829640/
https://ncbi.nlm.nih.gov/pubmed/26641029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/smll.201501985
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