siRNA nanoparticle suppresses drug-resistant gene and prolongs survival in an orthotopic glioblastoma xenograft mouse model

Temozolomide (TMZ) is the standard of care chemotherapy drug for treating glioblastomas (GBMs), the most aggressive cancer that affects people of all ages. However, its therapeutic efficacy is limited by the drug resistance mediated by a DNA repair protein, O(6)-methylguanine-DNA methyltransferase (...

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Detaylı Bibliyografya
Yayımlandı:Adv Funct Mater
Asıl Yazarlar: Wang, Kui, Kievit, Forrest M., Chiarelli, Peter A., Stephen, Zachary R., Lin, Guanyou, Silber, John R., Ellenbogen, Richard G., Zhang, Miqin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7942690/
https://ncbi.nlm.nih.gov/pubmed/33708035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adfm.202007166
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