siRNA nanoparticle suppresses drug-resistant gene and prolongs survival in an orthotopic glioblastoma xenograft mouse model

Temozolomide (TMZ) is the standard of care chemotherapy drug for treating glioblastomas (GBMs), the most aggressive cancer that affects people of all ages. However, its therapeutic efficacy is limited by the drug resistance mediated by a DNA repair protein, O(6)-methylguanine-DNA methyltransferase (...

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Detalhes bibliográficos
Publicado no:Adv Funct Mater
Main Authors: Wang, Kui, Kievit, Forrest M., Chiarelli, Peter A., Stephen, Zachary R., Lin, Guanyou, Silber, John R., Ellenbogen, Richard G., Zhang, Miqin
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7942690/
https://ncbi.nlm.nih.gov/pubmed/33708035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adfm.202007166
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