Iron oxide-based nanovector for tumor targeted siRNA delivery in an orthotopic hepatocellular carcinoma xenograft mouse model

Hepatocellular carcinoma (HCC) is one of the deadliest cancers worldwide. Small interfering RNA (siRNA) holds promise as a new class of therapeutics for HCC as it can achieve sequence-specific gene knockdown with low cytotoxicity. However, the main challenge in the clinical application of siRNA lies...

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Gepubliceerd in:Small
Hoofdauteurs: Wang, Kui, Kievit, Forrest M., Sham, Jonathan G., Jeon, Mike, Stephen, Zachary R., Bakthavatsalam, Arvind, Park, James O., Zhang, Miqin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4829640/
https://ncbi.nlm.nih.gov/pubmed/26641029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/smll.201501985
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