pH-sensitive siRNA Nanovector for Targeted Gene Silencing and Cytotoxic Effect in Cancer Cells

A small interfering RNA (siRNA) nanovector with dual targeting specificity and dual therapeutic effect is developed for targeted cancer imaging and therapy. The nanovector is comprised of an iron oxide magnetic nanoparticle core coated with three different functional molecules: polyethyleneimine (PE...

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Bibliographic Details
Main Authors: Mok, Hyejung, Veiseh, Omid, Fang, Chen, Kievit, Forrest M., Wang, Freddy Y., Park, James O., Zhang, Miqin
Format: Artigo
Language:Inglês
Published: 2010
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997854/
https://ncbi.nlm.nih.gov/pubmed/20722417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp100221h
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