Splicing-independent loading of TREX on nascent RNA is required for efficient expression of dual-strand piRNA clusters in Drosophila

The conserved THO/TREX (transcription/export) complex is critical for pre-mRNA processing and mRNA nuclear export. In metazoa, TREX is loaded on nascent RNA transcribed by RNA polymerase II in a splicing-dependent fashion; however, how TREX functions is poorly understood. Here we show that Thoc5 and...

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Bibliografiske detaljer
Udgivet i:Genes Dev
Main Authors: Hur, Junho K., Luo, Yicheng, Moon, Sungjin, Ninova, Maria, Marinov, Georgi K., Chung, Yun D., Aravin, Alexei A.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826399/
https://ncbi.nlm.nih.gov/pubmed/27036967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.276030.115
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