Multiple weak linear motifs enhance recruitment and processivity in SPOP-mediated substrate ubiquitination

Primary sequence motifs, with millimolar affinities for binding partners, are abundant in disordered protein regions. In multivalent interactions, such weak linear motifs can cooperate to recruit binding partners via avidity effects. If linear motifs recruit modifying enzymes, optimal placement of w...

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Publicat a:J Mol Biol
Autors principals: Pierce, Wendy K., Grace, Christy R., Lee, Jihun, Nourse, Amanda, Marzahn, Melissa R., Watson, Edmond R., High, Anthony A., Peng, Junmin, Schulman, Brenda A., Mittag, Tanja
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826287/
https://ncbi.nlm.nih.gov/pubmed/26475525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2015.10.002
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