Intrinsically disordered substrates dictate SPOP subnuclear localization and ubiquitination activity

Speckle-type POZ protein (SPOP) is a ubiquitin ligase adaptor that binds substrate proteins and facilitates their proteasomal degradation. Most SPOP substrates present multiple SPOP-binding (SB) motifs and undergo liquid–liquid phase separation with SPOP. Pancreatic and duodenal homeobox 1 (Pdx1), a...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Usher, Emery T., Sabri, Nafiseh, Rohac, Roman, Boal, Amie K., Mittag, Tanja, Showalter, Scott A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2021
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8138767/
https://ncbi.nlm.nih.gov/pubmed/33894201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100693
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