Cancer mutations of the tumor suppressor SPOP disrupt the formation of active, phase-separated compartments

Mutations in the tumor suppressor SPOP (Speckle-type POZ protein) cause prostate, breast and other solid tumors. SPOP is a substrate adaptor of the cullin3-RING ubiquitin ligase and localizes to nuclear speckles. Although cancer-associated mutations in SPOP interfere with substrate recruitment to th...

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Gepubliceerd in:Mol Cell
Hoofdauteurs: Bouchard, Jill J., Otero, Joel H., Scott, Daniel C., Szulc, Elzbieta, Martin, Erik W., Sabri, Nafiseh, Granata, Daniele, Marzahn, Melissa R., Lindorff-Larsen, Kresten, Salvatella, Xavier, Schulman, Brenda A., Mittag, Tanja
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6179159/
https://ncbi.nlm.nih.gov/pubmed/30244836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.08.027
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