Загрузка...
Cancer mutations of the tumor suppressor SPOP disrupt the formation of active, phase-separated compartments
Mutations in the tumor suppressor SPOP (Speckle-type POZ protein) cause prostate, breast and other solid tumors. SPOP is a substrate adaptor of the cullin3-RING ubiquitin ligase and localizes to nuclear speckles. Although cancer-associated mutations in SPOP interfere with substrate recruitment to th...
Сохранить в:
| Опубликовано в: : | Mol Cell |
|---|---|
| Главные авторы: | , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2018
|
| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6179159/ https://ncbi.nlm.nih.gov/pubmed/30244836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.08.027 |
| Метки: |
Добавить метку
Нет меток, Требуется 1-ая метка записи!
|