Φορτώνει......
Cancer mutations of the tumor suppressor SPOP disrupt the formation of active, phase-separated compartments
Mutations in the tumor suppressor SPOP (Speckle-type POZ protein) cause prostate, breast and other solid tumors. SPOP is a substrate adaptor of the cullin3-RING ubiquitin ligase and localizes to nuclear speckles. Although cancer-associated mutations in SPOP interfere with substrate recruitment to th...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Mol Cell |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2018
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6179159/ https://ncbi.nlm.nih.gov/pubmed/30244836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.08.027 |
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