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Multiple weak linear motifs enhance recruitment and processivity in SPOP-mediated substrate ubiquitination
Primary sequence motifs, with millimolar affinities for binding partners, are abundant in disordered protein regions. In multivalent interactions, such weak linear motifs can cooperate to recruit binding partners via avidity effects. If linear motifs recruit modifying enzymes, optimal placement of w...
में बचाया:
| में प्रकाशित: | J Mol Biol |
|---|---|
| मुख्य लेखकों: | , , , , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2015
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4826287/ https://ncbi.nlm.nih.gov/pubmed/26475525 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2015.10.002 |
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