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Multiple weak linear motifs enhance recruitment and processivity in SPOP-mediated substrate ubiquitination
Primary sequence motifs, with millimolar affinities for binding partners, are abundant in disordered protein regions. In multivalent interactions, such weak linear motifs can cooperate to recruit binding partners via avidity effects. If linear motifs recruit modifying enzymes, optimal placement of w...
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| Veröffentlicht in: | J Mol Biol |
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| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4826287/ https://ncbi.nlm.nih.gov/pubmed/26475525 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2015.10.002 |
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