Multiple weak linear motifs enhance recruitment and processivity in SPOP-mediated substrate ubiquitination

Primary sequence motifs, with millimolar affinities for binding partners, are abundant in disordered protein regions. In multivalent interactions, such weak linear motifs can cooperate to recruit binding partners via avidity effects. If linear motifs recruit modifying enzymes, optimal placement of w...

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Detalhes bibliográficos
Publicado no:J Mol Biol
Main Authors: Pierce, Wendy K., Grace, Christy R., Lee, Jihun, Nourse, Amanda, Marzahn, Melissa R., Watson, Edmond R., High, Anthony A., Peng, Junmin, Schulman, Brenda A., Mittag, Tanja
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826287/
https://ncbi.nlm.nih.gov/pubmed/26475525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2015.10.002
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