Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases

In the largest E3 ligase subfamily, Cul3 binds a BTB domain, and an associated protein-interaction domain such as MATH recruits substrates for ubiquitination. Here we present biochemical and structural analyses of the MATH-BTB protein, SPOP. We define a SPOP-binding consensus (SBC), and determine st...

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Autors principals: Zhuang, Min, Calabrese, Matthew F., Liu, Jiang, Waddell, M. Brett, Nourse, Amanda, Hammel, Michal, Miller, Darcie J., Walden, Helen, Duda, David M., Seyedin, Steven N., Hoggard, Timothy, Harper, J. Wade, White, Kevin P., Schulman, Brenda A.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2847577/
https://ncbi.nlm.nih.gov/pubmed/19818708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.09.022
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