Cooperative TRAIL production mediates IFNα/Smac mimetic-induced cell death in TNFα-resistant solid cancer cells

Smac mimetics antagonize IAP proteins, which are highly expressed in several cancers. Recent reports indicate that Smac mimetics trigger a broad cytokine response and synergize with immune modulators to induce cell death. Here, we identify a differential requirement of TRAIL or TNFα as mediators of...

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Bibliografiska uppgifter
I publikationen:Oncotarget
Huvudupphovsmän: Roesler, Stefanie, Eckhardt, Ines, Wolf, Sebastian, Fulda, Simone
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals LLC 2016
Ämnen:
Research paper: Autophagy and Cell Death
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826164/
https://ncbi.nlm.nih.gov/pubmed/26788912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6915
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