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Inhibition of polo like kinase 1 in sarcomas induces apoptosis that is dependent on Mcl-1 suppression
Sarcomas are rare cancers and the current treatments in inoperable or metastatic disease have not been shown to prolong survival. In order to develop novel targeted therapies, we tested the efficacy of polo-like kinase 1 (PLK-1) inhibitor (TAK-960) in sarcoma. All the sarcoma cell lines were sensiti...
Guardat en:
| Publicat a: | Cell Cycle |
|---|---|
| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Taylor & Francis
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4825583/ https://ncbi.nlm.nih.gov/pubmed/26236920 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1078033 |
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