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The induction of polyploidy or apoptosis by the Aurora A kinase inhibitor MK8745 is p53-dependent
Aurora kinases are mitotic serine/threonine protein kinases and are attractive novel targets for anticancer therapy. Many small-molecule inhibitors of Aurora kinases are currently undergoing clinical trials. Aurora A kinase is essential for successful mitotic transition. MK8745 is a novel and select...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3318110/ https://ncbi.nlm.nih.gov/pubmed/22293494 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.11.4.19323 |
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