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Inhibition of polo like kinase 1 in sarcomas induces apoptosis that is dependent on Mcl-1 suppression
Sarcomas are rare cancers and the current treatments in inoperable or metastatic disease have not been shown to prolong survival. In order to develop novel targeted therapies, we tested the efficacy of polo-like kinase 1 (PLK-1) inhibitor (TAK-960) in sarcoma. All the sarcoma cell lines were sensiti...
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| Publicado no: | Cell Cycle |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4825583/ https://ncbi.nlm.nih.gov/pubmed/26236920 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1078033 |
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