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Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells

Elevated expression of mammalian polo-like kinase (Plk)1 occurs in many different types of cancers, and Plk1 has been proposed as a novel diagnostic marker for several tumors. We used the recently developed vector-based small interfering RNA technique to specifically deplete Plk1 in cancer cells. We...

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Autori principali: Liu, Xiaoqi, Erikson, Raymond L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC156279/
https://ncbi.nlm.nih.gov/pubmed/12732729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1031523100
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