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Checkpoint kinase 1 (Chk1) is required for mitotic progression through negative regulation of polo-like kinase 1 (Plk1)

Although the essential function of checkpoint kinase 1 (Chk1) in DNA damage response has been well established, the role of Chk1 in normal cell cycle progression is unclear. By using RNAi to specifically deplete Chk1, we determined loss-of-function phenotypes in HeLa cells. A vector-based RNAi appro...

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Autors principals: Tang, Jiabin, Erikson, Raymond L., Liu, Xiaoqi
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1567681/
https://ncbi.nlm.nih.gov/pubmed/16873548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604987103
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