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Polo-Like Kinase 1 Depletion Induces DNA Damage in Early S Prior to Caspase Activation

Polo-like kinase 1 (Plk1) plays several roles in mitosis, and it has been suggested to have a role in tumorigenesis. We have previously reported that Plk1 depletion results in cell death in cancer cells, whereas normal cells survive similar depletion. However, Plk1 depletion together with p53 deplet...

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Bibliografski detalji
Glavni autori: Yim, Hyungshin, Erikson, Raymond L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682042/
https://ncbi.nlm.nih.gov/pubmed/19289504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01277-08
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