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Synergistic effects of hypertonic saline and valproic acid in a lethal rat two-hit model
BACKGROUND: Hemorrhagic shock (HS) followed by an infection (“second hit”) can lead to severe systemic inflammatory response and multiple-organ failure. Studies have shown that resuscitation with hypertonic saline (HTS) can blunt the inflammatory response. We demonstrated that large doses of valproi...
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| Publicado no: | J Trauma Acute Care Surg |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4824955/ https://ncbi.nlm.nih.gov/pubmed/23511136 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TA.0b013e31828583e3 |
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