Synergistic effects of hypertonic saline and valproic acid in a lethal rat two-hit model

BACKGROUND: Hemorrhagic shock (HS) followed by an infection (“second hit”) can lead to severe systemic inflammatory response and multiple-organ failure. Studies have shown that resuscitation with hypertonic saline (HTS) can blunt the inflammatory response. We demonstrated that large doses of valproi...

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Publicat a:J Trauma Acute Care Surg
Autors principals: Liu, Zhengcai, Li, Yongqing, Liu, Baoling, Deperalta, Danielle K., Zhao, Ting, Chong, Wei, Duan, Xiuzhen, Zhou, Peter, Velmahos, George C., Alam, Hasan B.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824955/
https://ncbi.nlm.nih.gov/pubmed/23511136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TA.0b013e31828583e3
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