Sparstolonin B attenuates early liver inflammation in experimental NASH by modulating TLR4 trafficking in lipid rafts via NADPH oxidase activation

Although significant research data exist on the pathophysiology of nonalcoholic steatohepatitis (NASH), finding an efficient treatment regimen for it remains elusive. The present study used sparstolonin B (SsnB), a novel TLR4 antagonist derived from the Chinese herb Sparganium stoloniferum, as a pos...

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Detalhes bibliográficos
Publicado no:Am J Physiol Gastrointest Liver Physiol
Main Authors: Dattaroy, Diptadip, Seth, Ratanesh Kumar, Das, Suvarthi, Alhasson, Firas, Chandrashekaran, Varun, Michelotti, Gregory, Fan, Daping, Nagarkatti, Mitzi, Nagarkatti, Prakash, Diehl, Anna Mae, Chatterjee, Saurabh
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2015
Assuntos:
Liver and Biliary Tract Physiology/Pathophysiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824178/
https://ncbi.nlm.nih.gov/pubmed/26718771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00259.2015
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