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RXR controlled regulatory networks identified in mouse brain counteract deleterious effects of Aβ oligomers
Bexarotene, a selective agonist for Retinoid X receptors (RXR) improves cognitive deficits and amyloid-β (Aβ) clearance in mice. Here we examine if the effect of bexarotene on RXR cistrome and transcriptomes depend on APOE isoform and Aβ deposition. We found bexarotene increased RXR binding to promo...
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| Foilsithe in: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
Nature Publishing Group
2016
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4823697/ https://ncbi.nlm.nih.gov/pubmed/27051978 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24048 |
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