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Role of prolyl hydroxylase domain proteins in the regulation of insulin secretion

Type 2 diabetes is associated with impaired nutrient‐regulated anaplerosis and insulin secretion in pancreatic β‐cells. One key anaplerotic substrate that may be involved in regulating insulin release is α‐ketoglutarate (αKG). Since prolyl hydroxylase domain proteins (PHDs) can metabolize cytosolic...

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Bibliographische Detailangaben
Veröffentlicht in:Physiol Rep
Hauptverfasser: Huang, Mei, Paglialunga, Sabina, Wong, Julia M.‐K., Hoang, Monica, Pillai, Renjitha, Joseph, Jamie W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4823601/
https://ncbi.nlm.nih.gov/pubmed/26997627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.12722
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