Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice

Prolyl endopeptidase (PREP) has been implicated in neuronal functions. Here we report that hypothalamic PREP is predominantly expressed in the ventromedial nucleus (VMH), where it regulates glucose-induced neuronal activation. PREP knockdown mice (Prep(gt/gt)) exhibited glucose intolerance, decrease...

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Detalhes bibliográficos
Main Authors: Kim, Jung Dae, Toda, Chitoku, D’Agostino, Giuseppe, Zeiss, Caroline J., DiLeone, Ralph J., Elsworth, John D., Kibbey, Richard G., Chan, Owen, Harvey, Brandon K., Richie, Christopher T., Savolainen, Mari, Myöhänen, Timo, Jeong, Jin Kwon, Diano, Sabrina
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136568/
https://ncbi.nlm.nih.gov/pubmed/25071172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1406000111
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