Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice

Prolyl endopeptidase (PREP) has been implicated in neuronal functions. Here we report that hypothalamic PREP is predominantly expressed in the ventromedial nucleus (VMH), where it regulates glucose-induced neuronal activation. PREP knockdown mice (Prep(gt/gt)) exhibited glucose intolerance, decrease...

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Bibliografiske detaljer
Main Authors: Kim, Jung Dae, Toda, Chitoku, D’Agostino, Giuseppe, Zeiss, Caroline J., DiLeone, Ralph J., Elsworth, John D., Kibbey, Richard G., Chan, Owen, Harvey, Brandon K., Richie, Christopher T., Savolainen, Mari, Myöhänen, Timo, Jeong, Jin Kwon, Diano, Sabrina
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136568/
https://ncbi.nlm.nih.gov/pubmed/25071172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1406000111
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