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The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse

The misfolding and aggregation of α-synuclein (aSyn) eventually leads to an accumulation of toxic forms that disturb normal neuronal function and result in cell death. aSyn rich inclusions are seen in Parkinson’s disease, dementia with Lewy bodies and other synucleinopathies. Prolyl oligopeptidase (...

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Dades bibliogràfiques
Publicat a:Neurobiol Dis
Autors principals: Savolainen, Mari H., Richie, Christopher T., Harvey, Brandon K., Männistö, Pekka T., Maguire-Zeiss, Kathleen A., Myöhänen, Timo T.
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7254878/
https://ncbi.nlm.nih.gov/pubmed/24746855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2014.04.003
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