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Removal of prolyl oligopeptidase reduces alpha-synuclein toxicity in cells and in vivo
Prolyl oligopeptidase (PREP) inhibition by small-molecule inhibitors can reduce alpha-synuclein (aSyn) aggregation, a key player in Parkinson’s disease pathology. However, the significance of PREP protein for aSyn aggregation and toxicity is not known. We studied this in vivo by using PREP knock-out...
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| Publié dans: | Sci Rep |
|---|---|
| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5784134/ https://ncbi.nlm.nih.gov/pubmed/29367610 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19823-y |
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