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Inhibition of Prolyl Oligopeptidase Restores Spontaneous Motor Behavior in the α-Synuclein Virus Vector–Based Parkinson's Disease Mouse Model by Decreasing α-Synuclein Oligomeric Species in Mouse Brain

Decreased clearance of α-synuclein (aSyn) and aSyn protein misfolding and aggregation are seen as major factors in the pathogenesis of Parkinson's disease (PD) and other synucleinopathies that leads to disruption in neuronal function and eventually to cell death. Prolyl oligopeptidase (PREP) ca...

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Bibliografske podrobnosti
izdano v:J Neurosci
Main Authors: Svarcbahs, Reinis, Julku, Ulrika H., Myöhänen, Timo T.
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601975/
https://ncbi.nlm.nih.gov/pubmed/27927963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2309-16.2016
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