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Prolyl Oligopeptidase Enhances α-Synuclein Dimerization via Direct Protein-Protein Interaction

Prolyl oligopeptidase (PREP) accelerates the aggregation of α-synuclein (aSyn), a key protein involved in development of Parkinson disease and other synucleinopathies. PREP inhibitors reduce aSyn aggregation, but the mechanism has remained unknown. We have now used protein-fragment complementation a...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Savolainen, Mari H., Yan, Xu, Myöhänen, Timo T., Huttunen, Henri J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335246/
https://ncbi.nlm.nih.gov/pubmed/25555914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.592931
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