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Prolyl Oligopeptidase Enhances α-Synuclein Dimerization via Direct Protein-Protein Interaction
Prolyl oligopeptidase (PREP) accelerates the aggregation of α-synuclein (aSyn), a key protein involved in development of Parkinson disease and other synucleinopathies. PREP inhibitors reduce aSyn aggregation, but the mechanism has remained unknown. We have now used protein-fragment complementation a...
Tallennettuna:
| Julkaisussa: | J Biol Chem |
|---|---|
| Päätekijät: | , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Society for Biochemistry and Molecular Biology
2015
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4335246/ https://ncbi.nlm.nih.gov/pubmed/25555914 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.592931 |
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