Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice

Prolyl endopeptidase (PREP) has been implicated in neuronal functions. Here we report that hypothalamic PREP is predominantly expressed in the ventromedial nucleus (VMH), where it regulates glucose-induced neuronal activation. PREP knockdown mice (Prep(gt/gt)) exhibited glucose intolerance, decrease...

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Autori principali: Kim, Jung Dae, Toda, Chitoku, D’Agostino, Giuseppe, Zeiss, Caroline J., DiLeone, Ralph J., Elsworth, John D., Kibbey, Richard G., Chan, Owen, Harvey, Brandon K., Richie, Christopher T., Savolainen, Mari, Myöhänen, Timo, Jeong, Jin Kwon, Diano, Sabrina
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2014
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136568/
https://ncbi.nlm.nih.gov/pubmed/25071172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1406000111
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