Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins

Polycythemia is often associated with erythropoietin (EPO) overexpression and defective oxygen sensing. In normal cells, intracellular oxygen concentrations are directly sensed by prolyl hydroxylase domain (PHD)–containing proteins, which tag hypoxia-inducible factor (HIF) α subunits for polyubiquit...

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Detalhes bibliográficos
Main Authors: Takeda, Kotaro, Aguila, Hector L., Parikh, Nehal S., Li, Xiping, Lamothe, Katie, Duan, Li-Juan, Takeda, Hiromi, Lee, Frank S., Fong, Guo-Hua
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Red Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265459/
https://ncbi.nlm.nih.gov/pubmed/18056838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-09-114561
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