Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins

Polycythemia is often associated with erythropoietin (EPO) overexpression and defective oxygen sensing. In normal cells, intracellular oxygen concentrations are directly sensed by prolyl hydroxylase domain (PHD)–containing proteins, which tag hypoxia-inducible factor (HIF) α subunits for polyubiquit...

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Main Authors: Takeda, Kotaro, Aguila, Hector L., Parikh, Nehal S., Li, Xiping, Lamothe, Katie, Duan, Li-Juan, Takeda, Hiromi, Lee, Frank S., Fong, Guo-Hua
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2008
Fag:
Red Cells
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265459/
https://ncbi.nlm.nih.gov/pubmed/18056838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-09-114561
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